Serological tests facilitate identification of asymptomatic SARS-CoV-2 infection in Wuhan, China.
Identifieur interne : 000243 ( Main/Exploration ); précédent : 000242; suivant : 000244Serological tests facilitate identification of asymptomatic SARS-CoV-2 infection in Wuhan, China.
Auteurs : Xiaodong Wu [République populaire de Chine] ; Bo Fu [République populaire de Chine] ; Lang Chen [République populaire de Chine] ; Yong Feng [République populaire de Chine]Source :
- Journal of medical virology [ 1096-9071 ] ; 2020.
Abstract
The Wuhan City has ended the lockdown and people have been allowed to resume working since April 8 if meeting a set of COVID-19-associated tests including SARS-CoV-2 nucleic acid test (NAT) of nasopharyngeal swabs, chest CT scan or a SARS-CoV-2-specific serological test. Here, we reported the positive rate of COVID-19 tests based on NAT, chest CT scan and a serological SARS-CoV-2 test, from April 3 to 15 in one hospital in Qingshan Destrict, Wuhan. We observed a ~10% SARS-CoV-2-specific IgG positive rate from 1,402 tests. Combination of SARS-CoV-2 NAT and a specific serological test might facilitate the detection of COVID-19 infection, or the asymptomatic SARS-CoV-2-infected subjects. Large-scale investigation is required to evaluate the herd immunity of the city, for the resuming people and for the re-opened city. This article is protected by copyright. All rights reserved.
DOI: 10.1002/jmv.25904
PubMed: 32311142
Affiliations:
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Critical Care Medicine, CR & WISCO General Hospital, Wuhan, 430080, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory and Critical Care Medicine, CR & WISCO General Hospital, Wuhan, 430080, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Fu, Bo" sort="Fu, Bo" uniqKey="Fu B" first="Bo" last="Fu">Bo Fu</name><affiliation wicri:level="1"><nlm:affiliation>Dept. of Clinical Laboratory, CR & WISCO General Hospital, Wuhan, 430080, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Dept. of Clinical Laboratory, CR & WISCO General Hospital, Wuhan, 430080, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Lang" sort="Chen, Lang" uniqKey="Chen L" first="Lang" last="Chen">Lang Chen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Immunology, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Immunology, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, Hubei</wicri:regionArea><orgName type="university">Université de Wuhan</orgName><placeName><settlement type="city">Wuhan</settlement><region type="province">Hubei</region></placeName></affiliation></author><author><name sortKey="Feng, Yong" sort="Feng, Yong" uniqKey="Feng Y" first="Yong" last="Feng">Yong Feng</name><affiliation wicri:level="4"><nlm:affiliation>State Key Laboratory of Virology/Department of Medical Microbiology, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Virology/Department of Medical Microbiology, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, Hubei</wicri:regionArea><orgName type="university">Université de Wuhan</orgName><placeName><settlement type="city">Wuhan</settlement><region type="province">Hubei</region></placeName></affiliation></author></analytic><series><title level="j">Journal of medical virology</title><idno type="eISSN">1096-9071</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Wuhan City has ended the lockdown and people have been allowed to resume working since April 8 if meeting a set of COVID-19-associated tests including SARS-CoV-2 nucleic acid test (NAT) of nasopharyngeal swabs, chest CT scan or a SARS-CoV-2-specific serological test. Here, we reported the positive rate of COVID-19 tests based on NAT, chest CT scan and a serological SARS-CoV-2 test, from April 3 to 15 in one hospital in Qingshan Destrict, Wuhan. We observed a ~10% SARS-CoV-2-specific IgG positive rate from 1,402 tests. Combination of SARS-CoV-2 NAT and a specific serological test might facilitate the detection of COVID-19 infection, or the asymptomatic SARS-CoV-2-infected subjects. Large-scale investigation is required to evaluate the herd immunity of the city, for the resuming people and for the re-opened city. This article is protected by copyright. All rights reserved.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Hubei</li></region><settlement><li>Wuhan</li></settlement><orgName><li>Université de Wuhan</li></orgName></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Wu, Xiaodong" sort="Wu, Xiaodong" uniqKey="Wu X" first="Xiaodong" last="Wu">Xiaodong Wu</name></noRegion><name sortKey="Chen, Lang" sort="Chen, Lang" uniqKey="Chen L" first="Lang" last="Chen">Lang Chen</name><name sortKey="Feng, Yong" sort="Feng, Yong" uniqKey="Feng Y" first="Yong" last="Feng">Yong Feng</name><name sortKey="Fu, Bo" sort="Fu, Bo" uniqKey="Fu B" first="Bo" last="Fu">Bo Fu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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